Tapering off Naltrexone
Also sold as ReVia, Vivitrol.
Naltrexone usually does not require a slow taper, but some people still prefer to ease off gradually. Here is what to expect when you stop, and how to plan any change with your prescriber.
Do you need to taper off Naltrexone?
Naltrexone does not cause the physical dependence that forces a slow taper, so it can usually be stopped without a formal step-down. Any change is still worth running past your prescriber, and some people prefer to reduce gently anyway, so the tools here work either way.
Naltrexone has a relatively short half-life (~4 h), so blood levels rise and fall between doses. That can make direct reductions feel abrupt and can cause interdose withdrawal, so steps are kept small and well spaced.
No withdrawal of its own; the key safety point is the reverse, you must be opioid-free for ~7–10 days before starting or it triggers acute opioid withdrawal, and opioid sensitivity rises after stopping.
See a Naltrexone taper curve
The real engine runs right here. Enter your daily dose to watch a hyperbolic schedule take shape, no signup.
Slow is the point: gradual tapers are why ~70% succeed where cold turkey fails. Your full plan adds safety screening, exact dose recipes, and adapts to your check-ins.
What your Naltrexone plan includes
Before any schedule, a short intake flags the situations where you should slow down or check with a clinician, so the plan starts from your actual picture.
A hyperbolic schedule sized to Naltrexone: the milligram cuts shrink as the dose falls, so the steps get gentler exactly where they need to.
The small end-of-taper doses made reachable. Below the smallest tablet, Subside spells out the practical options (careful splitting of the scored tablet or a compounding pharmacy) instead of leaving you to guess.
Your check-ins feed back into the plan: rough stretches trigger a hold or a gentler pace, and reinstatement (stepping back up to stabilize) is a first-class option, never a failure.
When symptoms show up, the plan reads them against the timing of your last reduction, so you can tell an expected wave from something that needs a different response.
Common questions about coming off Naltrexone
How long does a Naltrexone taper take?+
Naltrexone usually does not need a formal taper, so there is no fixed length; you can stop once you and your prescriber agree. If you would rather ease off, Subside can lay out a gentle optional step-down at whatever pace feels comfortable.
Can I stop Naltrexone cold turkey?+
Usually yes. Naltrexone does not cause physical dependence, so it can typically be stopped without a taper. Tell your prescriber first, and expect mainly the return of whatever it was treating.
What are common Naltrexone withdrawal symptoms?+
Discontinuation effects vary with the specific drug and dose; where they occur, they are usually mild on a gradual taper.
Do I need a doctor to taper off Naltrexone?+
Not for a taper itself: Naltrexone can usually be stopped without a formal step-down. Even so, any medication change is best made with the prescriber who knows your history, so let them know before you stop, especially if Naltrexone is treating something that could return. Subside can track how you feel through the change, and everydaymd® is a telehealth service whose clinicians can help if you would like guidance.